![]() ![]() Her research interests include mathematical modeling and investigation in cerebral hemodynamic processes, specifically cerebral vascular reactivity, and clinical investigation in the application of functioning imaging tools to investigate neurological disorders.IntroductionĬerebral blood flow (CBF) is carefully regulated to provide nutrients and oxygen to the various regions of the brain. She obtained her MSc in Biomedical Physics from Ryerson University, Toronto, Canada. Olivia Sobczyk is currently a PhD student in the Institute of Medical Science at the University of Toronto and the University Health Network, Toronto, Canada. His research interests include clinical investigations of cerebral vasculature pathophysiology and fMRI related research. His PhD degree from Utrecht University, was based on research done in the Department of Neurosurgery, Neuroradiology and Anesthesiology of the University Health Network, Toronto, Canada, and he recently received an MD degree from Utrecht University, the Netherlands. Jorn Fierstra is currently enrolled in a neurosurgical training program at the University Medical Center Zürich, Switzerland. We describe recently developed computer-controlled MRI compatible gas delivery systems which are capable of administering reliable and repeatable vasoactive CO 2 stimuli. We suggest that carbon dioxide is the most suitable vasoactive stimulus. We conclude that many of the stimuli in current use do not provide a standard stimulus comparable between individuals and in the same individual over time. Such challenges include induced reductions in systemic blood pressure, and the administration of vasoactive substances such as acetazolamide and carbon dioxide. This review therefore critically examines the vasoactive stimuli in current use for their ability to provide a standard repeatable challenge and for the practicality of their implementation. Indeed, the wide variety of vasoactive challenges currently employed in these studies impedes comparisons between them. While there are standardized and repeatable methods for estimating the changes in cerebral blood flow in response to a vasoactive stimulus, the same cannot be said for the stimulus itself. Measuring variations of cerebrovascular reactivity between different regions of the brain has the potential to not only advance understanding of how the cerebral vasculature controls the distribution of blood flow but also to detect cerebrovascular pathophysiology. b_4()Īt .AsyncControllerActionInvoker.c_Displa圜lass3_1.Cerebrovascular reactivity is the change in cerebral blood flow in response to a vasodilatory or vasoconstrictive stimulus. b_2()Īt .AsyncControllerActionInvoker.EndInvokeActionMethodWithFilters(IAsyncResult asyncResult)Īt .AsyncControllerActionInvoker.c_Displa圜lass3_6. b_1(IAsyncResult asyncResult)Īt .AsyncControllerActionInvoker.EndInvokeActionMethod(IAsyncResult asyncResult)Īt ._Displa圜lass11_0. d_27.MoveNext() in D:\MaverStation\WorkShop\BaiShiDeng\Wjgnet\BsdWebApp\BsdWebApp\Controllers\JournalController.cs:line 532Īt .TaskAsyncActionDescriptor.EndExecute(IAsyncResult asyncResult)Īt .AsyncControllerActionInvoker.c_Displa圜lass8_0. d_48.MoveNext() in D:\MaverStation\WorkShop\BaiShiDeng\Wjgnet\BsdWebApp\BsdWebApp\Controllers\JournalController.cs:line 863Īt. d_74.MoveNext() in D:\MaverStation\WorkShop\BaiShiDeng\Wjgnet\BsdWebApp\BsdWeb.Utility\Services\BsdRestService.cs:line 872Īt. d_11`1.MoveNext() in D:\MaverStation\WorkShop\BaiShiDeng\Wjgnet\BsdWebApp\BsdWeb.Utility\Services\ServiceHelper.cs:line 0Īt. d_24.MoveNext() in D:\MaverStation\WorkShop\BaiShiDeng\Wjgnet\BsdWebApp\\Services\JournalService.cs:line 349Īt. End of stack trace from previous location where exception was thrown -Īt .Throw()Īt .HandleNonSuccessAndDebuggerNotification(Task task)Īt. System.Exception: BadRequest|GetPublishedArticle?doi=10.5306/wjco.v2.i7.289Īt.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |